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L-5-Hydroxytryptophan
versus placebo in childhood migraine prophylaxis: a double-blind
crossover study
Margherita
Santucci11Childhood
Neuropsychiatry Chair, University of Bologna, Bologna, Italy; ,
Pietro Cortelli22Institute
of Clinical Neurology, University of Bologna, Bologna, Italy,
Paola Giovanardi Rossi11Childhood
Neuropsychiatry Chair, University of Bologna, Bologna, Italy; ,
Agostino Baruzzi22Institute
of Clinical Neurology, University of Bologna, Bologna, Italy,
Tommaso Sacquegna22Institute
of Clinical Neurology, University of Bologna, Bologna, Italy
Childhood Neuropsychiatry
Chair, University of Bologna, Bologna, Italy; 2Institute
of Clinical Neurology, University of Bologna, Bologna, Italy
Correspondence to Tommaso Sacquegna, Centro Cefalee, Clinica
Neurologica, Via U. Foscolo 7, 40123 Bologna, Italy;
L-5HTP was tested versus placebo in a double-blind crossover study of
27 migraine children aged 6–12 years, who recorded their headaches
in a headache diary for 1 month. Twenty-one patients subsequently
started the trial. The mean daily dose of L-5HTP was 5 mg/kg body
weight, and each treatment period with either L-5HTP or placebo
lasted 12 weeks. In group A (L-5HTP-placebo; 10 patients) and group B
(placebo-L-5HTP; 11 patients) both L-5HTP and placebo led to a
significant reduction of the migraine index and frequency of migraine
attacks during the 3rd month of each treatment period. However, we
found a treatment x period interaction because the efficacy
determinants decreased significantly during the first and the second
treatment periods in both groups irrespective of the sequence of
treatments. No differences were found between L-5HTP (first period of
group A) and placebo (first period of group B).
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